Ontology highlight
ABSTRACT:
SUBMITTER: Liu W
PROVIDER: S-EPMC2742434 | biostudies-literature | 2009 Sep
REPOSITORIES: biostudies-literature
Liu Wei W Li Dong D Wang Jian J Xie Hongwei H Zhu Yunping Y He Fuchu F
Molecular & cellular proteomics : MCP 20090605 9
Signal flow direction is one of the most important features of the protein-protein interactions in signaling networks. However, almost all the outcomes of current high-throughout techniques for protein-protein interactions mapping are usually supposed to be non-directional. Based on the pairwise interaction domains, here we defined a novel parameter protein interaction directional score and then used it to predict the direction of signal flow between proteins in proteome-wide signaling networks. ...[more]