Ontology highlight
ABSTRACT:
SUBMITTER: Dai JY
PROVIDER: S-EPMC2742496 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
Dai James Y JY Leblanc Michael M Smith Nicholas L NL Psaty Bruce B Kooperberg Charles C
Biostatistics (Oxford, England) 20090715 4
Association studies have been widely used to identify genetic liability variants for complex diseases. While scanning the chromosomal region 1 single nucleotide polymorphism (SNP) at a time may not fully explore linkage disequilibrium, haplotype analyses tend to require a fairly large number of parameters, thus potentially losing power. Clustering algorithms, such as the cladistic approach, have been proposed to reduce the dimensionality, yet they have important limitations. We propose a SNP-Hap ...[more]