Ontology highlight
ABSTRACT:
SUBMITTER: Borrok MJ
PROVIDER: S-EPMC2742562 | biostudies-literature | 2009 Jun
REPOSITORIES: biostudies-literature
Borrok M Jack MJ Zhu Yimin Y Forest Katrina T KT Kiessling Laura L LL
ACS chemical biology 20090601 6
Many receptors undergo ligand-induced conformational changes to initiate signal transduction. Periplasmic binding proteins (PBPs) are bacterial receptors that exhibit dramatic conformational changes upon ligand binding. These proteins mediate a wide variety of fundamental processes including transport, chemotaxis, and quorum sensing. Despite the importance of these receptors, no PBP antagonists have been identified and characterized. In this study, we identify 3-O-methyl-d-glucose as an antagoni ...[more]