Ontology highlight
ABSTRACT:
SUBMITTER: Schreeder DM
PROVIDER: S-EPMC2742621 | biostudies-literature | 2008 Nov
REPOSITORIES: biostudies-literature
Schreeder Daniel M DM Pan Jicun J Li Fu Jun FJ Vivier Eric E Davis Randall S RS
European journal of immunology 20081101 11
Fc receptor-like 6 (FCRL6), the most recently characterized member of the FCRL family, is a cell surface glycoprotein with tyrosine-based regulatory potential. An extensive survey of human hematopoietic tissues disclosed that FCRL6 expression by NK- and T-cell subpopulations increases as a function of differentiation and is remarkably restricted to mature lymphocytes with cytotoxic capability. In particular, FCRL6 distinguishes perforin-expressing CD56dim NK cells, Vdelta1+ and Vdelta2+ gammadel ...[more]