Skin-stage schistosomula of Schistosoma mansoni produce an apoptosis-inducing factor that can cause apoptosis of T cells.
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ABSTRACT:
SUBMITTER: Chen L
PROVIDER: S-EPMC2742670 | biostudies-literature | 2002 Sep
REPOSITORIES: biostudies-literature
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Skin-stage schistosomula of Schistosoma mansoni produce an apoptosis-inducing factor that can cause apoptosis of T cells.
Chen Lin L Rao Kakuturu V N KV He Yi-Xun YX Ramaswamy Kalyanasundaram K
The Journal of biological chemistry 20020709 37
Skin-stage schistosomula of Schistosoma mansoni were found to secrete molecules that are pro-apoptotic for skin T lymphocytes as measured by annexin V staining, caspase-3 activity, caspase-8 activities, and DNA fragmentation. Caspase-8 activities in lymphocytes peaked approximately 8 h and caspase-3 activity peaked approximately 16 h after exposure to the parasite secretions. Subset analysis showed that mainly CD4(+) and CD8(+) cells (but not B cells) were susceptible to the parasite-induced pro ...[more]
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