X-ray structure of Danio rerio secretagogin: A hexa-EF-hand calcium sensor.
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ABSTRACT:
SUBMITTER: Bitto E
PROVIDER: S-EPMC2742686 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
Publications
X-ray structure of Danio rerio secretagogin: A hexa-EF-hand calcium sensor.
Bitto Eduard E Bingman Craig A CA Bittova Lenka L Frederick Ronnie O RO Fox Brian G BG Phillips George N GN
Proteins 20090801 2
Many essential physiological processes are regulated by the modulation of calcium concentration in the cell. The EF-hand proteins represent a superfamily of calcium-binding proteins involved in calcium signaling and homeostasis. Secretagogin is a hexa-EF-hand protein that is highly expressed in pancreatic islet of Langerhans and neuroendocrine cells and may play a role in the trafficking of secretory granules. We present the X-ray structure of Danio rerio secretagogin, which is 73% identical to ...[more]
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