Ontology highlight
ABSTRACT:
SUBMITTER: Mathias JR
PROVIDER: S-EPMC2742687 | biostudies-literature | 2009 Nov
REPOSITORIES: biostudies-literature
Mathias Jonathan R JR Dodd M Ernest ME Walters Kevin B KB Yoo Sa Kan SK Ranheim Erik A EA Huttenlocher Anna A
Developmental and comparative immunology 20090729 11
Zebrafish have emerged as a powerful model system to study leukocyte recruitment and inflammation. Here we characterize the morphology and function of inflammatory macrophages in zebrafish larvae. These macrophages can be distinguished from neutrophils by immunolabeling of L-Plastin without MPO co-expression and by an elongated morphology. Live imaging of transgenic zMPO:GFP larvae demonstrate that GFP(lo) macrophages migrate to wounds by extension of thin pseudopods and carry out phagocytosis o ...[more]