Ontology highlight
ABSTRACT:
SUBMITTER: Raghuram S
PROVIDER: S-EPMC2743565 | biostudies-literature | 2007 Dec
REPOSITORIES: biostudies-literature
Raghuram Srilatha S Stayrook Keith R KR Huang Pengxiang P Rogers Pamela M PM Nosie Amanda K AK McClure Don B DB Burris Lorri L LL Khorasanizadeh Sepideh S Burris Thomas P TP Rastinejad Fraydoon F
Nature structural & molecular biology 20071125 12
The nuclear receptors REV-ERBalpha (encoded by NR1D1) and REV-ERBbeta (NR1D2) have remained orphans owing to the lack of identified physiological ligands. Here we show that heme is a physiological ligand of both receptors. Heme associates with the ligand-binding domains of the REV-ERB receptors with a 1:1 stoichiometry and enhances the thermal stability of the proteins. Results from experiments of heme depletion in mammalian cells indicate that heme binding to REV-ERB causes the recruitment of t ...[more]