Ontology highlight
ABSTRACT:
SUBMITTER: Chandra V
PROVIDER: S-EPMC2743566 | biostudies-literature | 2008 Nov
REPOSITORIES: biostudies-literature
Chandra Vikas V Huang Pengxiang P Hamuro Yoshitomo Y Raghuram Srilatha S Wang Yongjun Y Burris Thomas P TP Rastinejad Fraydoon F
Nature 20081101 7220
Nuclear receptors are multi-domain transcription factors that bind to DNA elements from which they regulate gene expression. The peroxisome proliferator-activated receptors (PPARs) form heterodimers with the retinoid X receptor (RXR), and PPAR-gamma has been intensively studied as a drug target because of its link to insulin sensitization. Previous structural studies have focused on isolated DNA or ligand-binding segments, with no demonstration of how multiple domains cooperate to modulate recep ...[more]