Ontology highlight
ABSTRACT:
SUBMITTER: Okada M
PROVIDER: S-EPMC2743618 | biostudies-literature | 2009 Sep
REPOSITORIES: biostudies-literature
Okada Masahiro M Okawa Katsuya K Isobe Toshiaki T Fukagawa Tatsuo T
Molecular biology of the cell 20090722 18
Centromere identity is thought to be determined by epigenetic mechanisms. The centromere-specific histone H3 variant CENP-A plays a central role in specifying the locus where the centromere is constructed. However, the precise mechanisms that target CENP-A to centromeric chromatin are poorly understood. Here, we show that facilitates chromatin transcription (FACT) localizes to centromeres in a CENP-H-containing complex-dependent manner. In conditional mutant cell lines for SSRP1, a subunit of FA ...[more]