Ontology highlight
ABSTRACT:
SUBMITTER: Chen MJ
PROVIDER: S-EPMC2744041 | biostudies-literature | 2009 Feb
REPOSITORIES: biostudies-literature
Chen Michael J MJ Yokomizo Tomomasa T Zeigler Brandon M BM Dzierzak Elaine E Speck Nancy A NA
Nature 20090107 7231
Haematopoietic stem cells (HSCs) are the founder cells of the adult haematopoietic system, and thus knowledge of the molecular program directing their generation during development is important for regenerative haematopoietic strategies. Runx1 is a pivotal transcription factor required for HSC generation in the vascular regions of the mouse conceptus-the aorta, vitelline and umbilical arteries, yolk sac and placenta. It is thought that HSCs emerge from vascular endothelial cells through the form ...[more]