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Smoking reduction with oral nicotine inhalers: double blind, randomised clinical trial of efficacy and safety.

ABSTRACT: OBJECTIVES:To determine whether use of an oral nicotine inhaler can result in long term reduction in smoking and whether concomitant use of nicotine replacement and smoking is safe. DESIGN:Double blind, randomised, placebo controlled trial. Four month trial with a two year follow up. SETTING:Two university hospital pulmonary clinics in Switzerland. PARTICIPANTS:400 healthy volunteers, recruited through newspaper advertisements, willing to reduce their smoking but unable or unwilling to stop smoking immediately. INTERVENTION:Active or placebo inhaler as needed for up to 18 months, with participants encouraged to limit their smoking as much as possible. MAIN OUTCOME MEASURES:Number of cigarettes smoked per day from week six to end point. Decrease verified by a measurement of exhaled carbon monoxide at each time point compared with measurement at baseline. RESULTS:At four months sustained reduction of smoking was achieved in 52 (26%) participants in the active group and 18 (9%) in the placebo group (P<0.001; Fisher's test). Corresponding figures after two years were 19 (9.5%) and 6 (3.0%) (P=0.012). CONCLUSION:Nicotine inhalers effectively and safely achieved sustained reduction in smoking over 24 months. Reduction with or without nicotine substitution may be a feasible first step towards smoking cessation in people not able or not willing to stop abruptly.

SUBMITTER: Bolliger CT

PROVIDER: S-EPMC27447 | biostudies-literature | 2000 Aug

REPOSITORIES: biostudies-literature

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Smoking reduction with oral nicotine inhalers: double blind, randomised clinical trial of efficacy and safety.

Bolliger C T CT Zellweger J P JP Danielsson T T van Biljon X X Robidou A A Westin A A Perruchoud A P AP Säwe U U

BMJ (Clinical research ed.) 20000801 7257

<h4>Objectives</h4>To determine whether use of an oral nicotine inhaler can result in long term reduction in smoking and whether concomitant use of nicotine replacement and smoking is safe.<h4>Design</h4>Double blind, randomised, placebo controlled trial. Four month trial with a two year follow up.<h4>Setting</h4>Two university hospital pulmonary clinics in Switzerland.<h4>Participants</h4>400 healthy volunteers, recruited through newspaper advertisements, willing to reduce their smoking but una ...[more]

PMID: 10926587

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Smoking reduction with oral nicotine inhalers: double blind, randomised clinical trial of efficacy and safety.

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Smoking reduction with oral nicotine inhalers: double blind, randomised clinical trial of efficacy and safety.

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