Ontology highlight
ABSTRACT:
SUBMITTER: Vanek V
PROVIDER: S-EPMC2744866 | biostudies-literature | 2009 Jun
REPOSITORIES: biostudies-literature
Vanek Václav V Budesínský Milos M Kabeleová Petra P Sanda Miloslav M Kozísek Milan M Hanclová Ivona I Mládková Jana J Brynda Jirí J Rosenberg Ivan I Koutmos Markos M Garrow Timothy A TA Jirácek Jirí J
Journal of medicinal chemistry 20090601 12
Betaine-homocysteine S-methyltransferase (BHMT) catalyzes the transfer of a methyl group from betaine to l-homocysteine, yielding dimethylglycine and l-methionine. In this study, we prepared a new series of BHMT inhibitors. The inhibitors were designed to mimic the hypothetical transition state of BHMT substrates and consisted of analogues with NH, N(CH(3)), or N(CH(3))(2) groups separated from the homocysteine sulfur atom by a methylene, ethylene, or a propylene spacer. Only the inhibitor with ...[more]