Ontology highlight
ABSTRACT:
SUBMITTER: Kim HJ
PROVIDER: S-EPMC2745060 | biostudies-literature | 2008 Dec
REPOSITORIES: biostudies-literature
Kim Hye-Jung HJ Jung Cha-Gyun CG Jensen Mark A MA Dukala Danuta D Soliven Betty B
Journal of immunology (Baltimore, Md. : 1950) 20081201 12
Elimination of the costimulatory molecule B7-2 prevents autoimmune diabetes in NOD mice, but leads to the development of a spontaneous autoimmune polyneuropathy (SAP), which resembles the human disease chronic inflammatory demyelinating polyneuropathy (CIDP). In this study, we examined the immunopathogenic mechanisms in this model, including identification of SAP Ags. We found that B7-2-deficient NOD mice exhibit changes in cytokine and chemokine gene expression in spleens over time. There was a ...[more]