Ontology highlight
ABSTRACT:
SUBMITTER: Lipscomb GL
PROVIDER: S-EPMC2745277 | biostudies-literature | 2009 Jan
REPOSITORIES: biostudies-literature
Lipscomb Gina L GL Keese Annette M AM Cowart Darin M DM Schut Gerrit J GJ Thomm Michael M Adams Michael W W MW Adams Michael W W MW Scott Robert A RA
Molecular microbiology 20081110 2
This work describes the identification and characterization of SurR, Pyrococcus furiosus sulphur (S(0)) response regulator. SurR was captured from cell extract using promoter DNA of a hydrogenase operon that is downregulated in the primary response of P. furiosus to S(0), as revealed by DNA microarray experiments. SurR was validated as a sequence-specific DNA binding protein, and characterization of the SurR DNA binding motif GTTn(3)AAC led to the identification of several target genes that cont ...[more]