Ontology highlight
ABSTRACT:
SUBMITTER: Stoller D
PROVIDER: S-EPMC2745323 | biostudies-literature | 2007 Oct
REPOSITORIES: biostudies-literature
Stoller Douglas D Kakkar Rahul R Smelley Matthew M Chalupsky Karel K Earley Judy U JU Shi Nian-Qing NQ Makielski Jonathan C JC McNally Elizabeth M EM
Journal of molecular and cellular cardiology 20070801 4
Adenosine triphosphate-sensitive potassium (K(ATP)) channels are thought to mediate the stress response by sensing intracellular ATP concentration. Cardiomyocyte K(ATP) channels are composed of the pore-forming Kir6.2 subunit and the regulatory sulfonylurea receptor 2 (SUR2). We studied the response to acute isoproterenol in SUR2 null mice as a model of acute adrenergic stress and found that the episodic coronary vasospasm observed at baseline in SUR2 null mice was alleviated. Similar results we ...[more]