Ontology highlight
ABSTRACT:
SUBMITTER: Nilsson R
PROVIDER: S-EPMC2745341 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
Nilsson Roland R Schultz Iman J IJ Pierce Eric L EL Soltis Kathleen A KA Naranuntarat Amornrat A Ward Diane M DM Baughman Joshua M JM Paradkar Prasad N PN Kingsley Paul D PD Culotta Valeria C VC Kaplan Jerry J Palis James J Paw Barry H BH Mootha Vamsi K VK
Cell metabolism 20090801 2
Heme biosynthesis consists of a series of eight enzymatic reactions that originate in mitochondria and continue in the cytosol before returning to mitochondria. Although these core enzymes are well studied, additional mitochondrial transporters and regulatory factors are predicted to be required. To discover such unknown components, we utilized a large-scale computational screen to identify mitochondrial proteins whose transcripts consistently coexpress with the core machinery of heme biosynthes ...[more]