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Mapping of the full length and the truncated interleukin-18 receptor alpha in the mouse brain.

ABSTRACT: The cytokine IL-18 acts on the CNS both in physiological and pathological conditions. Its action occurs through the heterodimeric receptor IL-18Ralpha\beta. To better understand IL-18 central effects, we investigated in the mouse brain the distribution of two IL-18Ralpha transcripts, a full length and an isoform lacking the intracellular domain hypothesized to be a decoy receptor. Both isoforms were expressed in neurons throughout the brain primarily with overlapping distribution but also with some unique pattern. These data suggest that IL-18 may modulate neuronal functions and that its action may be regulated through expression of a decoy receptor.

SUBMITTER: Alboni S

PROVIDER: S-EPMC2745497 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature

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Mapping of the full length and the truncated interleukin-18 receptor alpha in the mouse brain.

Alboni Silvia S Cervia Davide D Ross Brendon B Montanari Claudia C Gonzalez Alejandro Sanchez AS Sanchez-Alavez Manuel M Marcondes Maria Cecilia Garibaldi MC De Vries David D Sugama Shuei S Brunello Nicoletta N Blom Joan J Tascedda Fabio F Tascedda Fabio F Conti Bruno B

Journal of neuroimmunology 20090728 1-2

The cytokine IL-18 acts on the CNS both in physiological and pathological conditions. Its action occurs through the heterodimeric receptor IL-18Ralpha\beta. To better understand IL-18 central effects, we investigated in the mouse brain the distribution of two IL-18Ralpha transcripts, a full length and an isoform lacking the intracellular domain hypothesized to be a decoy receptor. Both isoforms were expressed in neurons throughout the brain primarily with overlapping distribution but also with s ...[more]

PMID: 19640592

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