Ontology highlight
ABSTRACT:
SUBMITTER: Ghosh AK
PROVIDER: S-EPMC2745598 | biostudies-literature | 2008 Nov
REPOSITORIES: biostudies-literature
Ghosh Arun K AK Chapsal Bruno D BD Baldridge Abigail A Ide Kazuhiko K Koh Yashiro Y Mitsuya Hiroaki H
Organic letters 20081018 22
The synthesis of a series of stereochemically defined spirocyclic compounds and their use as novel P2-ligands for HIV-1 protease inhibitors are described. The bicyclic core of the ligands was synthesized by an efficient nBu 3SnH-promoted radical cyclization of a 1,6-enyne followed by oxidative cleavage. Structure-based design, synthesis of ligands, and biological evaluations of the resulting inhibitors are reported. ...[more]