Ontology highlight
ABSTRACT:
SUBMITTER: Jin L
PROVIDER: S-EPMC2745821 | biostudies-literature | 2008 Jul
REPOSITORIES: biostudies-literature
Jin Lan L Li Yun Y Chen Charng-Jui CJ Sherman Mark A MA Le Keith K Shively John E JE
Experimental biology and medicine (Maywood, N.J.) 20080429 7
CEACAM1-4L (carcinoembryonic antigen cell adhesion molecule 1, with 4 extracellular Ig-like domains and a long, 71 amino acid cytoplasmic domain) is expressed in epithelial cells and activated T-cells, but is down-regulated in most epithelial cell cancers and T-cell leukemias. A highly conserved sequence within the cytoplasmic domain has ca 50% sequence homology with Tcf-3 and -4, transcription factors that bind beta-catenin, and to a lesser extent (32% homology), with E-cadherin that also binds ...[more]