Ontology highlight
ABSTRACT:
SUBMITTER: Xu J
PROVIDER: S-EPMC2746052 | biostudies-literature | 2009 Mar
REPOSITORIES: biostudies-literature
Xu Jian J Zhu Yongling Y Contractor Anis A Heinemann Stephen F SF
The Journal of neuroscience : the official journal of the Society for Neuroscience 20090301 12
The mechanisms that contribute to the extinction of previously acquired memories are not well understood. These processes, often referred to as inhibitory learning, are thought to be parallel learning mechanisms that require a reacquisition of new information and suppression of previously acquired experiences in order to adapt to novel situations. Using newly generated metabotropic glutamate receptor 5 (mGluR5) knock-out mice, we investigated the role of mGluR5 in the acquisition and reversal of ...[more]