Ontology highlight
ABSTRACT:
SUBMITTER: Kanki T
PROVIDER: S-EPMC2746076 | biostudies-literature | 2009 Jul
REPOSITORIES: biostudies-literature
Developmental cell 20090701 1
Mitochondrial quality control is important in maintaining proper cellular homeostasis. Although selective mitochondrial degradation by autophagy (mitophagy) is suggested to have an important role in quality control, and though there is evidence for a direct relation between mitophagy and neurodegenerative diseases, the molecular mechanism of mitophagy is poorly understood. Using a screen for mitophagy-deficient mutants, we found that YIL146C/ECM37 is essential for mitophagy. This gene is not req ...[more]