Ontology highlight
ABSTRACT:
SUBMITTER: Halin M
PROVIDER: S-EPMC2746472 | biostudies-literature | 2009 Sep
REPOSITORIES: biostudies-literature
Halin Marilène M Douceron Estelle E Clerc Isabelle I Journo Chloé C Ko Nga Ling NL Landry Sébastien S Murphy Edward L EL Gessain Antoine A Lemasson Isabelle I Mesnard Jean-Michel JM Barbeau Benoît B Mahieux Renaud R
Blood 20090714 12
Human T-cell leukemia virus type 1 (HTLV-1) and type 2 (HTLV-2) retroviruses infect T lymphocytes. The minus strand of the HTLV-1 genome encodes HBZ, a protein that could play a role in the development of leukemia in infected patients. Herein, we demonstrate that the complementary strand of the HTLV-2 genome also encodes a protein that we named APH-2 for "antisense protein of HTLV-2." APH-2 mRNA is spliced, polyadenylated, and initiates in the 3'-long terminal repeat at different positions. This ...[more]