Ontology highlight
ABSTRACT:
SUBMITTER: Kadiu I
PROVIDER: S-EPMC2746502 | biostudies-literature | 2009
REPOSITORIES: biostudies-literature
Kadiu Irena I Wang Tong T Schlautman Joshua D JD Dubrovsky Larisa L Ciborowski Pawel P Bukrinsky Michael M Gendelman Howard E HE
Cellular immunology 20090408 1
How HIV-1 affects the monocyte proteome is incompletely understood. We posit that one functional consequence of virus-exposure to the monocyte is the facilitation of protein transformation from the cytosol to the plasma membrane (PM). To test this, cell surface labeling with CyDye fluorophores followed by 2 dimensional differential in-gel electrophoresis (2D DIGE) and liquid chromatography tandem mass spectrometry (LC-MS/MS) was performed. Fifty three percent of HIV-1 induced proteins were PM as ...[more]