Transglutaminase activation in neurodegenerative diseases.
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ABSTRACT:
SUBMITTER: Jeitner TM
PROVIDER: S-EPMC2746681 | biostudies-literature | 2009 Jul
REPOSITORIES: biostudies-literature
Publications
Transglutaminase activation in neurodegenerative diseases.
Jeitner Thomas M TM Muma Nancy A NA Battaile Kevin P KP Cooper Arthur Jl AJ
Future neurology 20090701 4
The following review examines the role of calcium in promoting the in vitro and in vivo activation of transglutaminases in neurodegenerative disorders. Diseases such as Alzheimer's disease, Parkinson's disease and Huntington's disease exhibit increased transglutaminase activity and rises in intracellular calcium concentrations, which may be related. The aberrant activation of transglutaminase by calcium is thought to give rise to a variety of pathological moieties in these diseases, and the inhi ...[more]
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