NADPH oxidase is the primary source of superoxide induced by NMDA receptor activation.
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ABSTRACT:
SUBMITTER: Brennan AM
PROVIDER: S-EPMC2746760 | biostudies-literature | 2009 Jul
REPOSITORIES: biostudies-literature
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NADPH oxidase is the primary source of superoxide induced by NMDA receptor activation.
Brennan Angela M AM Suh Sang Won SW Won Seok Joon SJ Narasimhan Purnima P Kauppinen Tiina M TM Lee Hokyou H Edling Ylva Y Chan Pak H PH Swanson Raymond A RA
Nature neuroscience 20090607 7
Neuronal NMDA receptor (NMDAR) activation leads to the formation of superoxide, which normally acts in cell signaling. With extensive NMDAR activation, the resulting superoxide production leads to neuronal death. It is widely held that NMDA-induced superoxide production originates from the mitochondria, but definitive evidence for this is lacking. We evaluated the role of the cytoplasmic enzyme NADPH oxidase in NMDA-induced superoxide production. Neurons in culture and in mouse hippocampus respo ...[more]
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