Genotype score in addition to common risk factors for prediction of type 2 diabetes.

ABSTRACT:

Background

Multiple genetic loci have been convincingly associated with the risk of type 2 diabetes mellitus. We tested the hypothesis that knowledge of these loci allows better prediction of risk than knowledge of common phenotypic risk factors alone.

Methods

We genotyped single-nucleotide polymorphisms (SNPs) at 18 loci associated with diabetes in 2377 participants of the Framingham Offspring Study. We created a genotype score from the number of risk alleles and used logistic regression to generate C statistics indicating the extent to which the genotype score can discriminate the risk of diabetes when used alone and in addition to clinical risk factors.

Results

There were 255 new cases of diabetes during 28 years of follow-up. The mean (+/-SD) genotype score was 17

SUBMITTER: Meigs JB 

PROVIDER: S-EPMC2746946 | biostudies-literature | 2008 Nov

REPOSITORIES: biostudies-literature