Ontology highlight
ABSTRACT:
SUBMITTER: Fujita K
PROVIDER: S-EPMC2747267 | biostudies-literature | 2009 Sep
REPOSITORIES: biostudies-literature
Fujita Kyota K Seike Toshihiro T Yutsudo Noriko N Ohno Mizuki M Yamada Hidetaka H Yamaguchi Hiroo H Sakumi Kunihiko K Yamakawa Yukiko Y Kido Mizuho A MA Takaki Atsushi A Katafuchi Toshihiko T Tanaka Yoshinori Y Nakabeppu Yusaku Y Noda Mami M
PloS one 20090930 9
It has been shown that molecular hydrogen (H(2)) acts as a therapeutic antioxidant and suppresses brain injury by buffering the effects of oxidative stress. Chronic oxidative stress causes neurodegenerative diseases such as Parkinson's disease (PD). Here, we show that drinking H(2)-containing water significantly reduced the loss of dopaminergic neurons in PD model mice using both acute and chronic administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). The concentration-dependency ...[more]