Genetic variation in the transforming growth factor-beta1 gene is associated with susceptibility to IgA nephropathy.
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ABSTRACT:
SUBMITTER: Vuong MT
PROVIDER: S-EPMC2747497 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
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Genetic variation in the transforming growth factor-beta1 gene is associated with susceptibility to IgA nephropathy.
Vuong Mai Tuyet MT Lundberg Sigrid S Gunnarsson Iva I Wramner Lars L Seddighzadeh Maria M Hahn-Zoric Mirjana M Fernström Anders A Hanson Lars A LA Do Lieu Thi LT Jacobson Stefan H SH Padyukov Leonid L
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20090303 10
<h4>Background</h4>There is growing evidence of genetic risk for susceptibility to IgA nephropathy. Among several candidate genes related to immunological regulation in renal tissue, TGFB1 is known to be a contributor to proliferation and the development of fibrosis.<h4>Methods</h4>We analysed several SNPs in a region of this gene using 212 DNA samples from biopsy-proven IgA nephropathy patients, 146 men and 66 women and 477 healthy age-matched controls (321 men and 156 women) from the same popu ...[more]
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