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Typical 2-Cys peroxiredoxins--structures, mechanisms and functions.

ABSTRACT: Peroxiredoxins are abundant cellular antioxidant proteins that help to control intracellular peroxide levels. These proteins may also function, in part, through an evolved sensitivity of some peroxiredoxins towards peroxide-mediated inactivation in hydrogen peroxide signaling in eukaryotes. This review summarizes recent progress in our understanding of the catalytic and regulatory mechanisms of 'typical 2-Cys' peroxiredoxins and of the biological roles played by these important enzymes in oxidative stress and nonstress-related cellular signaling. New evidence suggests localized peroxide buildup plays a role in nonstress-related signaling.

SUBMITTER: Hall A

PROVIDER: S-EPMC2747500 | biostudies-literature | 2009 May

REPOSITORIES: biostudies-literature

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Typical 2-Cys peroxiredoxins--structures, mechanisms and functions.

Hall Andrea A Karplus P A PA Poole Leslie B LB

The FEBS journal 20090324 9

Peroxiredoxins are abundant cellular antioxidant proteins that help to control intracellular peroxide levels. These proteins may also function, in part, through an evolved sensitivity of some peroxiredoxins towards peroxide-mediated inactivation in hydrogen peroxide signaling in eukaryotes. This review summarizes recent progress in our understanding of the catalytic and regulatory mechanisms of 'typical 2-Cys' peroxiredoxins and of the biological roles played by these important enzymes in oxidat ...[more]

PMID: 19476488

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Reduction of cysteine sulfinic acid in eukaryotic, typical 2-Cys peroxiredoxins by sulfiredoxin.

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Project description: Not available

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A role for 2-Cys peroxiredoxins in facilitating cytosolic protein thiol oxidation.

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