Ontology highlight
ABSTRACT:
SUBMITTER: Liu CI
PROVIDER: S-EPMC2747771 | biostudies-literature | 2008 Mar
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20080214 5868
Staphylococcus aureus produces hospital- and community-acquired infections, with methicillin-resistant S. aureus posing a serious public health threat. The golden carotenoid pigment of S. aureus, staphyloxanthin, promotes resistance to reactive oxygen species and host neutrophil-based killing, and early enzymatic steps in staphyloxanthin production resemble those for cholesterol biosynthesis. We determined the crystal structures of S. aureus dehydrosqualene synthase (CrtM) at 1.58 angstrom resol ...[more]