Ontology highlight
ABSTRACT:
SUBMITTER: Kim DY
PROVIDER: S-EPMC2747787 | biostudies-literature | 2007 Jul
REPOSITORIES: biostudies-literature
Kim Doo Yeon DY Carey Bryce W BW Wang Haibin H Ingano Laura A M LA Binshtok Alexander M AM Wertz Mary H MH Pettingell Warren H WH He Ping P Lee Virginia M-Y VM Woolf Clifford J CJ Kovacs Dora M DM
Nature cell biology 20070618 7
BACE1 activity is significantly increased in the brains of Alzheimer's disease patients, potentially contributing to neurodegeneration. The voltage-gated sodium channel (Na(v)1) beta2-subunit (beta2), a type I membrane protein that covalently binds to Na(v)1 alpha-subunits, is a substrate for BACE1 and gamma-secretase. Here, we find that BACE1-gamma-secretase cleavages release the intracellular domain of beta2, which increases mRNA and protein levels of the pore-forming Na(v)1.1 alpha-subunit in ...[more]