Ontology highlight
ABSTRACT:
SUBMITTER: Glazer DS
PROVIDER: S-EPMC2748254 | biostudies-literature | 2009 Jul
REPOSITORIES: biostudies-literature
Glazer Dariya S DS Radmer Randall J RJ Altman Russ B RB
Structure (London, England : 1993) 20090701 7
The number of molecules with solved three-dimensional structure but unknown function is increasing rapidly. Particularly problematic are novel folds with little detectable similarity to molecules of known function. Experimental assays can determine the functions of such molecules, but are time-consuming and expensive. Computational approaches can identify potential functional sites; however, these approaches generally rely on single static structures and do not use information about dynamics. In ...[more]