Ontology highlight
ABSTRACT:
SUBMITTER: Winter H
PROVIDER: S-EPMC2748340 | biostudies-literature | 2009 Feb
REPOSITORIES: biostudies-literature
Winter Harald H Rüttiger Lukas L Müller Marcus M Kuhn Stephanie S Brandt Niels N Zimmermann Ulrike U Hirt Bernhard B Bress Andreas A Sausbier Matthias M Conscience Aude A Flamant Frederic F Tian Yong Y Zuo Jian J Pfister Markus M Ruth Peter P Löwenheim Hubert H Samarut Jacques J Engel Jutta J Knipper Marlies M
The Journal of neuroscience : the official journal of the Society for Neuroscience 20090201 8
Thyroid hormone receptor beta (TRbeta) dysfunction leads to deafness in humans and mice. Deafness in TRbeta(-/-) mutant mice has been attributed to TRbeta-mediated control of voltage- and Ca(2+)-activated K(+) (BK) channel expression in inner hair cells (IHCs). However, normal hearing in young constitutive BKalpha(-/-) mutants contradicts this hypothesis. Here, we show that mice with hair cell-specific deletion of TRbeta after postnatal day 11 (P11) have a delay in BKalpha expression but normal ...[more]