Analysis of the matrix metalloproteinase family reveals that MMP8 is often mutated in melanoma.
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ABSTRACT:
SUBMITTER: Palavalli LH
PROVIDER: S-EPMC2748394 | biostudies-literature | 2009 May
REPOSITORIES: biostudies-literature
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Analysis of the matrix metalloproteinase family reveals that MMP8 is often mutated in melanoma.
Palavalli Lavanya H LH Prickett Todd D TD Wunderlich John R JR Wei Xiaomu X Burrell Allison S AS Porter-Gill Patricia P Davis Sean S Wang Chenwei C Cronin Julia C JC Agrawal Neena S NS Lin Jimmy C JC Westbroek Wendy W Hoogstraten-Miller Shelley S Molinolo Alfredo A AA Fetsch Patricia P Filie Armando C AC O'Connell Michael P MP Banister Carolyn E CE Howard Jason D JD Buckhaults Phillip P Weeraratna Ashani T AT Brody Lawrence C LC Rosenberg Steven A SA Samuels Yardena Y
Nature genetics 20090329 5
A mutational analysis of the matrix metalloproteinase (MMP) gene family in human melanoma identified somatic mutations in 23% of melanomas. Five mutations in one of the most commonly mutated genes, MMP8, reduced MMP enzyme activity. Expression of wild-type but not mutant MMP8 in human melanoma cells inhibited growth on soft agar in vitro and tumor formation in vivo, suggesting that wild-type MMP-8 has the ability to inhibit melanoma progression. ...[more]
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