Ontology highlight
ABSTRACT:
SUBMITTER: Gillette JM
PROVIDER: S-EPMC2748410 | biostudies-literature | 2009 Mar
REPOSITORIES: biostudies-literature
Nature cell biology 20090208 3
Haematopoietic stem-progenitor cells (HSPCs) reside in the bone marrow niche, where interactions with osteoblasts provide essential cues for their proliferation and survival. Here, we use live-cell imaging to characterize both the site of contact between osteoblasts and haematopoietic progenitor cells (HPCs) and events at this site that result in downstream signalling responses important for niche maintenance. HPCs made prolonged contact with the osteoblast surface through a specialized membrane ...[more]