Ontology highlight
ABSTRACT:
SUBMITTER: Ooi CH
PROVIDER: S-EPMC2748685 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
Ooi Chia Huey CH Ivanova Tatiana T Wu Jeanie J Lee Minghui M Tan Iain Beehuat IB Tao Jiong J Ward Lindsay L Koo Jun Hao JH Gopalakrishnan Veena V Zhu Yansong Y Cheng Lai Ling LL Lee Julian J Rha Sun Young SY Chung Hyun Cheol HC Ganesan Kumaresan K So Jimmy J Soo Khee Chee KC Lim Dennis D Chan Weng Hoong WH Wong Wai Keong WK Bowtell David D Yeoh Khay Guan KG Grabsch Heike H Boussioutas Alex A Tan Patrick P
PLoS genetics 20091002 10
Many solid cancers are known to exhibit a high degree of heterogeneity in their deregulation of different oncogenic pathways. We sought to identify major oncogenic pathways in gastric cancer (GC) with significant relationships to patient survival. Using gene expression signatures, we devised an in silico strategy to map patterns of oncogenic pathway activation in 301 primary gastric cancers, the second highest cause of global cancer mortality. We identified three oncogenic pathways (proliferatio ...[more]