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Multiplicity of diverse heterocycles from polymer-supported alpha-acylamino ketones.

ABSTRACT: Polymer-supported alpha-acylamino ketones were transformed to seven types of structurally unrelated heterocyclic compounds. Syntheses involved variety of chemical routes and comprised diverse chemistries (C-C, C=C, C-N, C=N, and C-O bond formations). Different sizes of heterocycles (4-, 5-, 6-, and 7-membered rings) were prepared, including dihydro-pyrrol-2-ones, pyrazin-2-ones, dihydro-triazepin-6-ones, morpholin-3-ones, imidazoles, beta-lactams, and isoquinolin-1-ones. Further elaboration to fused ring systems was also documented.

SUBMITTER: Pudelova N

PROVIDER: S-EPMC2748803 | biostudies-literature | 2009 Sep-Oct

REPOSITORIES: biostudies-literature

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Multiplicity of diverse heterocycles from polymer-supported alpha-acylamino ketones.

Pudelová Nadezda N Krchnák Viktor V

Journal of combinatorial chemistry 20090901 5

Polymer-supported alpha-acylamino ketones were transformed to seven types of structurally unrelated heterocyclic compounds. Syntheses involved variety of chemical routes and comprised diverse chemistries (C-C, C=C, C-N, C=N, and C-O bond formations). Different sizes of heterocycles (4-, 5-, 6-, and 7-membered rings) were prepared, including dihydro-pyrrol-2-ones, pyrazin-2-ones, dihydro-triazepin-6-ones, morpholin-3-ones, imidazoles, beta-lactams, and isoquinolin-1-ones. Further elaboration to f ...[more]

PMID: 19689103

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