Ontology highlight
ABSTRACT:
SUBMITTER: Depetris RS
PROVIDER: S-EPMC2748937 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
Depetris Rafael S RS Wu Jinhua J Hubbard Stevan R SR
Nature structural & molecular biology 20090802 8
Growth factor receptor-binding proteins Grb7, Grb10 and Grb14 are adaptor proteins containing a Ras-associating (RA) domain, a pleckstrin-homology (PH) domain, a family-specific BPS (between PH and SH2) region and a C-terminal Src-homology-2 domain. Previous structural studies showed that the Grb14 BPS region binds as a pseudosubstrate inhibitor in the tyrosine kinase domain of the insulin receptor to suppress insulin signaling. Here we report the crystal structure of the RA and PH domains of Gr ...[more]