Ontology highlight
ABSTRACT:
SUBMITTER: Goode EL
PROVIDER: S-EPMC2749057 | biostudies-literature | 2009 Sep
REPOSITORIES: biostudies-literature
Goode Ellen L EL Szabo Csilla C Prokunina-Olsson Ludmila L Vierkant Robert A RA Fredericksen Zachary S ZS Collins Francis S FS White Kristin L KL Schmidt Michele M Fridley Brooke L BL Couch Fergus J FJ
BMC cancer 20090904
<h4>Background</h4>TCF7L2 is a transcription factor involved in Wnt/beta-catenin signaling which has a variant known to be associated with risk of Type 2 diabetes and, in some studies, with risk of certain cancers, including familial breast cancer. No studies of ovarian cancer have been reported to date.<h4>Methods</h4>Two clinic-based case-control studies at the Mayo Clinic were assessed including 798 breast cancer cases, 843 breast cancer controls, 391 ovarian cancer cases, and 458 ovarian can ...[more]