Ontology highlight
ABSTRACT:
SUBMITTER: Hol J
PROVIDER: S-EPMC2749127 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
Hol Johanna J Küchler Axel M AM Johansen Finn-Eirik FE Dalhus Bjørn B Haraldsen Guttorm G Oynebråten Inger I
The Journal of biological chemistry 20090703 35
Sorting of proteins to Weibel-Palade bodies (WPB) of endothelial cells allows rapid regulated secretion of leukocyte-recruiting P-selectin and chemokines as well as procoagulant von Willebrand factor (VWF). Here we show by domain swap studies that the exposed aspartic acid in loop 2 (Ser(44)-Asp(45)-Gly(46)) of the CXC chemokine interleukin (IL)-8 is crucial for targeting to WPB. Loop 2 also governs sorting of chemokines to alpha-granules of platelets, but the fingerprint of the loop 2 of these ...[more]