Latent bone metastasis in breast cancer tied to Src-dependent survival signals.
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ABSTRACT:
SUBMITTER: Zhang XH
PROVIDER: S-EPMC2749247 | biostudies-literature | 2009 Jul
REPOSITORIES: biostudies-literature
Publications
Latent bone metastasis in breast cancer tied to Src-dependent survival signals.
Zhang Xiang H-F XH Wang Qiongqing Q Gerald William W Hudis Clifford A CA Norton Larry L Smid Marcel M Foekens John A JA Massagué Joan J
Cancer cell 20090701 1
Metastasis may arise years after removal of a primary tumor. The mechanisms allowing latent disseminated cancer cells to survive are unknown. We report that a gene expression signature of Src activation is associated with late-onset bone metastasis in breast cancer. This link is independent of hormone receptor status or breast cancer subtype. In breast cancer cells, Src is dispensable for homing to the bones or lungs but is critical for the survival and outgrowth of these cells in the bone marro ...[more]
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