Monte carlo simulation-based algorithms for analysis of shotgun proteomic data.
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ABSTRACT:
SUBMITTER: Xu H
PROVIDER: S-EPMC2749500 | biostudies-literature | 2008 Jul
REPOSITORIES: biostudies-literature
Publications
Monte carlo simulation-based algorithms for analysis of shotgun proteomic data.
Journal of proteome research 20080611 7
Two new statistical models based on Monte Carlo Simulation (MCS) have been developed to score peptide matches in shotgun proteomic data and incorporated in a database search program, MassMatrix (www.massmatrix.net). The first model evaluates peptide matches based on the total abundance of matched peaks in the experimental spectra. The second model evaluates amino acid residue tags within MS/MS spectra. The two models provide complementary scores for peptide matches that result in higher confiden ...[more]
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