Ontology highlight
ABSTRACT:
SUBMITTER: Yao CK
PROVIDER: S-EPMC2749961 | biostudies-literature | 2009 Sep
REPOSITORIES: biostudies-literature
Yao Chi-Kuang CK Lin Yong Qi YQ Ly Cindy V CV Ohyama Tomoko T Haueter Claire M CM Moiseenkova-Bell Vera Y VY Wensel Theodore G TG Bellen Hugo J HJ
Cell 20090901 5
Synaptic vesicle (SV) exo- and endocytosis are tightly coupled to sustain neurotransmission in presynaptic terminals, and both are regulated by Ca(2+). Ca(2+) influx triggered by voltage-gated Ca(2+) channels is necessary for SV fusion. However, extracellular Ca(2+) has also been shown to be required for endocytosis. The intracellular Ca(2+) levels (<1 microM) that trigger endocytosis are typically much lower than those (>10 microM) needed to induce exocytosis, and endocytosis is inhibited when ...[more]