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HAT-HDAC interplay modulates global histone H3K14 acetylation in gene-coding regions during stress.


ABSTRACT: Histone acetylation and deacetylation are important for gene regulation. The histone acetyltransferase, Gcn5, is an activator of transcriptional initiation that is recruited to gene promoters. Here, we map genome-wide Gcn5 occupancy and histone H3K14ac at high resolution. Gcn5 is predominantly localized to coding regions of highly transcribed genes, where it collaborates antagonistically with the class-II histone deacetylase, Clr3, to modulate H3K14ac levels and transcriptional elongation. An interplay between Gcn5 and Clr3 is crucial for the regulation of many stress-response genes. Our findings suggest a new role for Gcn5 during transcriptional elongation, in addition to its known role in transcriptional initiation.

SUBMITTER: Johnsson A 

PROVIDER: S-EPMC2750064 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature

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HAT-HDAC interplay modulates global histone H3K14 acetylation in gene-coding regions during stress.

Johnsson Anna A   Durand-Dubief Mickaël M   Xue-Franzén Yongtao Y   Rönnerblad Michelle M   Ekwall Karl K   Wright Anthony A  

EMBO reports 20090724 9


Histone acetylation and deacetylation are important for gene regulation. The histone acetyltransferase, Gcn5, is an activator of transcriptional initiation that is recruited to gene promoters. Here, we map genome-wide Gcn5 occupancy and histone H3K14ac at high resolution. Gcn5 is predominantly localized to coding regions of highly transcribed genes, where it collaborates antagonistically with the class-II histone deacetylase, Clr3, to modulate H3K14ac levels and transcriptional elongation. An in  ...[more]

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