Ontology highlight
ABSTRACT:
SUBMITTER: Wu H
PROVIDER: S-EPMC2750887 | biostudies-literature | 2009 Aug-Sep
REPOSITORIES: biostudies-literature
Wu Hai H Wang Meng C MC Bohmann Dirk D
Mechanisms of development 20090618 8-9
JNK signaling functions to induce defense mechanisms that protect organisms against acute oxidative and xenobiotic insults. Using Drosophila as a model system, we investigated the role of autophagy as such a JNK-regulated protective mechanism. We show that oxidative stress can induce autophagy in the intestinal epithelium by a mechanism that requires JNK signaling. Consistently, artificial activation of JNK in the gut gives rise to an autophagy phenotype. JNK signaling can induce the expression ...[more]