Ontology highlight
ABSTRACT:
SUBMITTER: List K
PROVIDER: S-EPMC2751542 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
List Karin K Kosa Peter P Szabo Roman R Bey Alexandra L AL Wang Chao Becky CB Molinolo Alfredo A Bugge Thomas H TH
The American journal of pathology 20090828 4
A pericellular proteolytic pathway initiated by the transmembrane serine protease matriptase plays a critical role in the terminal differentiation of epidermal tissues. Matriptase is constitutively expressed in multiple other epithelia, suggesting a putative role of this membrane serine protease in general epithelial homeostasis. Here we generated mice with conditional deletion of the St14 gene, encoding matriptase, and show that matriptase indeed is essential for the maintenance of multiple typ ...[more]