Ontology highlight
ABSTRACT:
SUBMITTER: Reed SA
PROVIDER: S-EPMC2751613 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
Reed Sean A SA Mazzotti Anthony R AR White M Christina MC
Journal of the American Chemical Society 20090801 33
A Brønsted base activation mode for oxidative, Pd(II)/sulfoxide-catalyzed, intermolecular C-H allylic amination is reported. N,N-diisopropylethylamine was found to promote amination of unactivated terminal olefins, forming the corresponding linear allylic amine products with high levels of stereo-, regio-, and chemoselectivity. The predictable and high selectivity of this C-H oxidation method enables late-stage incorporation of nitrogen into advanced synthetic intermediates and natural products. ...[more]