Ontology highlight
ABSTRACT:
SUBMITTER: Terrados G
PROVIDER: S-EPMC2751832 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
Terrados Gloria G Capp Jean-Pascal JP Canitrot Yvan Y García-Díaz Miguel M Bebenek Katarzyna K Kirchhoff Tomas T Villanueva Alberto A Boudsocq François F Bergoglio Valérie V Cazaux Christophe C Kunkel Thomas A TA Hoffmann Jean-Sébastien JS Blanco Luis L
PloS one 20091006 10
<h4>Background</h4>DNA polymerase lambda (Pollambda) is a DNA repair polymerase, which likely plays a role in base excision repair (BER) and in non-homologous end joining (NHEJ) of DNA double-strand breaks (DSB).<h4>Principal findings</h4>Here, we described a novel natural allelic variant of human Pollambda (hPollambda) characterized by a single nucleotide polymorphism (SNP), C/T variation in the first base of codon 438, resulting in the amino acid change Arg to Trp. In vitro enzyme activity ass ...[more]