Ontology highlight
ABSTRACT:
SUBMITTER: Paula S
PROVIDER: S-EPMC2752035 | biostudies-literature | 2009 Sep
REPOSITORIES: biostudies-literature
Bioorganic & medicinal chemistry 20090804 18
Analogues of the compound 2,5-di-tert-butylhydroquinone (BHQ) are capable of inhibiting the enzyme sarco/endoplasmic reticulum ATPase (SERCA) in the low micromolar and submicromolar concentration ranges. Not only are SERCA inhibitors valuable research tools, but they also have potential medicinal value as agents against prostate cancer. This study describes the synthesis of 13 compounds representing several classes of BHQ analogues, such as hydroquinones with a single aromatic substituent, symme ...[more]